Your priority is finding a way to set off the wrapped candies on the bottom of the screen - this will cause a cascade that will destroy the bomb and give you more space to create more combinations.
Most of the combinations will be created in the bottom board, but always look at the sides for possibilities.
Create horizontal striped candy near the bottom initially to set off the wrapped candies. This will destroy the bomb and open up the bottom. Aim a vertical striped candy to get the last wrapped down from the top, and you should only have a couple left to make yourself.