The placement of jelly is very high and inconvenient, and add to the fact that the jelly squares are separated from the other parts of the board, making the only practical way of destroying them is by using color bombs.
The difficulty lies within getting the target score. However there are different causes for getting the target score between Facebook and mobile. For Facebook, jelly fishes are nerfed, so in Sugar Crush you will not get as many points as you would get in mobile devices. The jelly fish aren't nerfed on iOS devices, so getting the 50,000 target score is easier on that platform.
The best and quick shortcut way to clear the jellies is the colour bomb + striped candy combo. As horizontal striped candies are near impossible to create high up in the first row, colour bombs are mandatory.
However, be mindful of the passing score requirement. Even after the Sugar Crush, there are chances that the jelly fish do not help you enough to reach 50,000 points, the passing score. Therefore, in order to pass, clearing the jellies with a few moves as possible is required.
To reach a 3-star score, try to utilize multiple colour bombs for bonus points. A lot of luck is needed for this method to work.
Another strategy is to use the colour bomb+wrapped combo. Firstly, more points can be reached. Secondly, because there are only 4 colours, so the chances of a layer of jelly being cleared are high.